Did any one ever think!!! " A road side herb, a herb which is found in the waste land would be soo beneficial for human kind..???? yes it is. I want to badly say that Lantana camara is a marvellous herb. there are many proofs for that. I my self proved two activities on this plant.This plant has perfect chemical constituents which are found to fetch tons of medical advantages.
Mayee R(2011) Evaluated the Antiurolithiac and Antioxidant activity of Lantana camara L. in rats. The roots of Lantana camara Linn. are recommended for kidney stone disorders in the Indian traditional system of medicine. Ethanolic extract of Lantana camara Linn. Leaves were evaluated for antiurolithiatic activity against 0.75% v/v ethylene glycol and 2% w/v ammonium chloride induced calcium oxalate urolithiasis and for antioxidant activity against hyperoxaluria induced oxidative stress in male albino rats. Ethylene glycol and ammonium chloride administration increased the deposition of calcium and oxalate in the kidneys; also increased urinary excretion of calcium oxalate and creatinine in the preventive and curative control rats. In these groups, increased levels of malondialdehyde, depleted levels of antioxidant enzymes, reduced glutathione and catalase were observed. On treatment with the extract, a significant reduction in the deposition of calcium, oxalate and also urinary excretion of calcium, oxalate and creatinine was observed, indicating its antiurolithiatic effect. The extract administration also decreased the extent of lipid peroxidation and hence enhanced the levels of antioxidant enzymes in the kidneys of urolithic rats, reflecting its antioxidant efficacy against hyperoxaluria induced renal oxidative stress. Results of the present study support the traditional claim of Lantana camara Linn. leaves in treating renal calculi
O. O. Oyedapo et al (2010) evaluated the Extracts of Lantana camara L. and its fractions for Red blood cell membrane stabilizing potentials. Anti-inflammatory activity of extract of Lantana camara, Linn and its fractions was investigated using stabilization of red blood cell membrane lysing technique. Phytochemically, whole plant extract (WPE) and ethanol fraction (EF) gave positive reactions for the presence of saponins, tannins, flavonoids and cardiac glycosides. The ethyl acetate fraction (EAF) gave reactions for the presence of flavonoids while butanol fraction (BF) gave positive test for the presence of saponins. The percentage membrane stability exhibited by the extract and various fractions was concentration dependent and compared favorably with those of standard drugs (Ibuprofen and Indomethacin). The results revealed that both ethanol and ethyl acetate fractions contained principles that protected the erythrocyte membranes effectively. Moreover, ethyl acetate fraction provided highest protection against induced lyses and exhibited both monophasic and biphasic responses at all the concentrations assayed.
BK Gidwani, Sushil Bhargava and SP Rao(2009) Evaluated the Analgesic, Anti-Inflammatory and Anti-Hemorrhoidal Activiy of Aqueous Extract of Lantana camara Linn. The aqueous extract of aerial parts of the plant Lantana camara was examined for the analgesic (hot plate method), anti–inflammatory (carrageenan induced paw oedema test) activities in albino rats by oral and topical routes respectively. The anti– hemorrhoidal activity was carried on patients using capsules prepared from dry aqueous extract of Lantana camara under the supervision of Chief medical officer, Department of shalya tantra Govt. Ayurvedic hospital, Nagpur.
O. Oluwadayo Sonibare (aug2008) Evaluated the Anti-Bacterial And Cytotoxicity of essential oil of Lantana camara L. leaves .The chemical composition of essential oil obtained from air-dried leaves of Lantana camara L. by 74.8%of the oil were identified. The main constituents were 1,8-cineol (15.8%), sabinene (14.7%) and caryophylene (8.9%). The essential oil was tested for antibacterial activity against 6 strains, using discdiffusion method, and for cytotoxicity using brine-shrimp lethality assay. The oil showed hydrodistillation was analyzed by GC and GC-MS. A total of thirty-two compounds representing moderate activity against Candida albican, Bacillus subtilis, Staphylococcus typhi, Pseudomonas aeruginosa and Bacillus aureus. These activities support its potential use as a remedy for bacterial infectious diseases.The essential oil with LC50 value of 0.01 was found to be highly toxic.
Nayak and Raju(2008) Investigated the wound healing activity of Lantama camara L. in Sprague dawley rats using a burn wound model. Lantana camara is used in herbal medicine for the treatment of skin itches, as an antiseptic for wounds, and externally for leprosy and scabies. The objective of our study is to investigate burn wound healing activity of the leaf extract of L.camara in rats. The animals were divided into two groups of 6 each. The test group animals were treated with the ethanol extract of L. camara (100mg kg-1 day-1) topically and the control group animals were left untreated. Healing was assessed by the rate of wound contraction, period of epithelialization. Antimicrobial activities of the extract against the specific microorganisms were assessed. The extract showed antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae and E.coli. Extract treated wounds were healedin about 21 days which is not distinct from the controls. Our data suggest that L.camara has antimicrobial activity but not wound healing promoting activity on burn wound.
M. Sathish Kumar and S. Maneemegalai (2008) Evaluated the Larvicidal effect of Lantana camara Linn Against Mosquito Species Aedes aegypti and Culex quinquefasciatus. Mosquito larvicidal activity and phytochemical screening of methanol and ethanol extract of leaves and flowers of Lantana camara Linn belongs to the family of Verbanaceae have been evaluated in the present study. Larvicidal effect on 3 and 4 instar larvae of mosquito species Aedes aegypti and Culex rd th quinquefasciatus have been investigated in a dose dependent manner for 24 h. With 1.0 mg/ml concentration of extracts of Lantana camara maximum mortality was observed in Aedes aegypti exposed for 24 h. In the case of Culex quinquefasciatus the mortality was seen maximised when the concentration increased to 3.0mg/ml. Presence of saponin, flavonoids, terpenoids and cardiac glycosides have also been observed and GC/MS analysis was carried out on methanol flower and leaf extract to find out the components.
Rohit Gundamaraju evaluated the Anti-obesity activity of Lantana camara(2012):
Mayee R(2011) Evaluated the Antiurolithiac and Antioxidant activity of Lantana camara L. in rats. The roots of Lantana camara Linn. are recommended for kidney stone disorders in the Indian traditional system of medicine. Ethanolic extract of Lantana camara Linn. Leaves were evaluated for antiurolithiatic activity against 0.75% v/v ethylene glycol and 2% w/v ammonium chloride induced calcium oxalate urolithiasis and for antioxidant activity against hyperoxaluria induced oxidative stress in male albino rats. Ethylene glycol and ammonium chloride administration increased the deposition of calcium and oxalate in the kidneys; also increased urinary excretion of calcium oxalate and creatinine in the preventive and curative control rats. In these groups, increased levels of malondialdehyde, depleted levels of antioxidant enzymes, reduced glutathione and catalase were observed. On treatment with the extract, a significant reduction in the deposition of calcium, oxalate and also urinary excretion of calcium, oxalate and creatinine was observed, indicating its antiurolithiatic effect. The extract administration also decreased the extent of lipid peroxidation and hence enhanced the levels of antioxidant enzymes in the kidneys of urolithic rats, reflecting its antioxidant efficacy against hyperoxaluria induced renal oxidative stress. Results of the present study support the traditional claim of Lantana camara Linn. leaves in treating renal calculi
O. O. Oyedapo et al (2010) evaluated the Extracts of Lantana camara L. and its fractions for Red blood cell membrane stabilizing potentials. Anti-inflammatory activity of extract of Lantana camara, Linn and its fractions was investigated using stabilization of red blood cell membrane lysing technique. Phytochemically, whole plant extract (WPE) and ethanol fraction (EF) gave positive reactions for the presence of saponins, tannins, flavonoids and cardiac glycosides. The ethyl acetate fraction (EAF) gave reactions for the presence of flavonoids while butanol fraction (BF) gave positive test for the presence of saponins. The percentage membrane stability exhibited by the extract and various fractions was concentration dependent and compared favorably with those of standard drugs (Ibuprofen and Indomethacin). The results revealed that both ethanol and ethyl acetate fractions contained principles that protected the erythrocyte membranes effectively. Moreover, ethyl acetate fraction provided highest protection against induced lyses and exhibited both monophasic and biphasic responses at all the concentrations assayed.
BK Gidwani, Sushil Bhargava and SP Rao(2009) Evaluated the Analgesic, Anti-Inflammatory and Anti-Hemorrhoidal Activiy of Aqueous Extract of Lantana camara Linn. The aqueous extract of aerial parts of the plant Lantana camara was examined for the analgesic (hot plate method), anti–inflammatory (carrageenan induced paw oedema test) activities in albino rats by oral and topical routes respectively. The anti– hemorrhoidal activity was carried on patients using capsules prepared from dry aqueous extract of Lantana camara under the supervision of Chief medical officer, Department of shalya tantra Govt. Ayurvedic hospital, Nagpur.
O. Oluwadayo Sonibare (aug2008) Evaluated the Anti-Bacterial And Cytotoxicity of essential oil of Lantana camara L. leaves .The chemical composition of essential oil obtained from air-dried leaves of Lantana camara L. by 74.8%of the oil were identified. The main constituents were 1,8-cineol (15.8%), sabinene (14.7%) and caryophylene (8.9%). The essential oil was tested for antibacterial activity against 6 strains, using discdiffusion method, and for cytotoxicity using brine-shrimp lethality assay. The oil showed hydrodistillation was analyzed by GC and GC-MS. A total of thirty-two compounds representing moderate activity against Candida albican, Bacillus subtilis, Staphylococcus typhi, Pseudomonas aeruginosa and Bacillus aureus. These activities support its potential use as a remedy for bacterial infectious diseases.The essential oil with LC50 value of 0.01 was found to be highly toxic.
Nayak and Raju(2008) Investigated the wound healing activity of Lantama camara L. in Sprague dawley rats using a burn wound model. Lantana camara is used in herbal medicine for the treatment of skin itches, as an antiseptic for wounds, and externally for leprosy and scabies. The objective of our study is to investigate burn wound healing activity of the leaf extract of L.camara in rats. The animals were divided into two groups of 6 each. The test group animals were treated with the ethanol extract of L. camara (100mg kg-1 day-1) topically and the control group animals were left untreated. Healing was assessed by the rate of wound contraction, period of epithelialization. Antimicrobial activities of the extract against the specific microorganisms were assessed. The extract showed antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae and E.coli. Extract treated wounds were healedin about 21 days which is not distinct from the controls. Our data suggest that L.camara has antimicrobial activity but not wound healing promoting activity on burn wound.
M. Sathish Kumar and S. Maneemegalai (2008) Evaluated the Larvicidal effect of Lantana camara Linn Against Mosquito Species Aedes aegypti and Culex quinquefasciatus. Mosquito larvicidal activity and phytochemical screening of methanol and ethanol extract of leaves and flowers of Lantana camara Linn belongs to the family of Verbanaceae have been evaluated in the present study. Larvicidal effect on 3 and 4 instar larvae of mosquito species Aedes aegypti and Culex rd th quinquefasciatus have been investigated in a dose dependent manner for 24 h. With 1.0 mg/ml concentration of extracts of Lantana camara maximum mortality was observed in Aedes aegypti exposed for 24 h. In the case of Culex quinquefasciatus the mortality was seen maximised when the concentration increased to 3.0mg/ml. Presence of saponin, flavonoids, terpenoids and cardiac glycosides have also been observed and GC/MS analysis was carried out on methanol flower and leaf extract to find out the components.
Rohit Gundamaraju evaluated the Anti-obesity activity of Lantana camara(2012):
The hypolipidemic activity of
Lantana camara was studied on high fat dieinduced models of hyperlipedemia in rats. Hyper lipidemia condition
established by butter was evidenced by enhancement in levels of cholesterol,
tri-glycerides, LDL, VLDL. Methanolic extract showed significant
hypolipidemic effect by lowering of serum levels of serum cholesterol, TG,
LDL, VLDL and increased dl level. Ethanobotanical knowledge of medicinal
plants is some of the most prominent source of new drugs and has shown
potential results for treatment of obesity. Prelimnary phytochemical analysis
revealed thye presence of phyto constituents such as steroids, flavinoids,
alkaloids.ROHIT GUNDAMARAJU has evaluated the anti-arthritic activity of Lantana camara.
The present study is designed to investigate the effect of anti-arthritic activity of Lantana
camara var Linn leaves extract on albino rats. In this abstraction, the acute non
immunological model was followed. The arthritis was induced with turpentine.
Lantana
camara
has been traditionally used to treat conditions like pain and also been proven to
treat various infections. The plant is found to have anti-bacterial,anti-viral, and
anti-infectious properties. With the help of ethano pharmacological survey the study was
performed. Ethanolic extract of Lantana camara showed significant (P<0.05) and dose
dependent inhibitory effect against acute model of arthritis. In this study an ethanolic
extract of Lantana camara showed better anti-arthritic activity than aspirin.
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